Course for international guest/part time students
- Faculty
- Faculty of Science
- Organization
- TTK Department of Organic Chemistry
- Code
- biopeptk20em
- Title
- Biologically Active Peptides
- Usual semester
- Autumn
- Published semester
- 2026/27/1
- ECTS
- 4
- Language
- en
- Learning outcomes
- a) Knowledge - Basic knowledge of peptide chemistry, which is a special part of organic chemistry, will be provided by the lecture including synthetic procedures, protecting groups, coupling procedures and coupling agents, side reactions and analysis. b) Abilities - The aim of the lecture that the students could be able to select the best methods for synthesis of peptides, can develop the synthetic protocol, can recognize the problems and improve them during their laboratory work in this field. c) Attitude - Try to catch the knowledge for the realization of their own scientific goals and can make independent decision based on this background. d) Autonomy and responsibility - They act independently in the development of comprehensive and specific professional issues, representing professional views.
- Course content
- The lecture presents the procedures of peptide synthesis including solution syntheses that is rather used in pharmaceutical companies and solid phase peptide synthesis applied mainly in research institutes. In frame of this the applied protecting groups, their incorporation and cleavage will be discussed. In addition, coupling procedures, coupling agents used in peptide chemistry will be presented. An important topic is the side reactions and how they can be avoided. The advantages and disadvantages of the procedures will be discussed. During the semester the students will get important suggestions and useful protocols for the lab work that might be useful for the preparation of their master thesis (who will work on this field)
- Assessment method
- First the students must answer 8 questions in written, that cover the whole topic of the lecture including developments of two peptide synthesis (one in solution and one on solid support). After that we will discuss about their answers and furthers should be answered orally. The result/mark will be provided according to their production and their skills for development of peptide synthesis have higher influence on the mark than the lexical knowledge, K(5).
- Bibliography
- Medzihradszky Kálmán: A természetes peptidek szintézise. A kémia újabb eredményei 3 (1970) Bajusz Sándor: Peptidszintézis. A kémia újabb eredményei 47 (1980) J.M. Stewart, J.D. Young: Solid phase peptide synthesis (Pierce Chemical Company, Rockford, 1984) E. Atherton, R.C. Sheppard: Solid phase peptide synthesis: a practical approach (IRL Press, Oxford, England, 1989) G.A. Grant: Synthetic peptides, a user´s guide (Freeman and Co., New York, 1992)