Course for international guest/part time students

Faculty

Faculty of Science

Organization

TTK Department of Inorganic Chemistry

Code

heterocyck20em

Title

Chemistry of Heteroaromatics

Usual semester

Autumn

Published semester

2026/27/1

ECTS

4

Language

en

Learning outcomes

a) Knowledge - Comprehensive knowledge about the prototypes of reactions employed in synthetic organic- and organometallic chemistry. Concepts of mechanistic organic chemistry with the special regards to the electronic- and stereostructure and basic organic reactions.  Chemical bonding and its description by valence bond method and simplified MO theory at qualitative level are of pronounced importance. The basics of stereochemistry. Structure-reactivity relationships that can be interpreted by resonance structures and steric interactions. b) Abilities - Ability of rational combination of molecular building blocks. Utilization of the acquired knowledge in solving solving complex synthetic problems utilizing the retrosynthetic analysis of the targeted products. Ability to find and to explore the information from the literature and the available chemical data bases. c) Attitude - The students are expected to seek to work on their own. They have to be ready to extend their knowledge in the discipline that can be exploited in the realisation of their professional purposes in their carreer. It is also desirable that the students show interest towards the applied heterocyclic chemistry with particular regard to pharmaceutical chemistry. d) Autonomy and responsibility - Hold responsibility for making decisions on his/her study. Make a point of solving separately the study cases assigned by the lecturer to him/her. Responsible application of the knowledge acquired in the course of his/her study.

Course content

Synthetic procedures affording a variety of heteroaromatic compounds of different ring size. Presentation of a variety of methods suitable to functionalisation of hetreoaromatics and to the modification of the pending substituents. Synthetic methods based on ring transformation, the mechanism of rearrangement reactions. Possibilities of the synthesis of compounds with important applications including bioactive products.

Assessment method

Written exam at the end of the semester with five-scale assessment, K(5).

Bibliography

John A. Tyrell, Louis D. Quin Fundamentals of Heterocyclic Chemistry ohn Wiley & Sons, 2010. J. J. Li and G. W. Gribble, Palladium in Heterocyclic Chemistry, Elsevier Science; 2 edition (January 2, 2007) A. F. Pozharskii, A. T. Soldatenkov, A. R. Katritzky, Heterocycles in Life and Society, John Wiley & Sons, 2011.

Programmes of the course