Course for international guest/part time students

Faculty

Faculty of Science

Organization

TTK Department of Organic Chemistry

Code

orgsynthlabk22lm

Title

Organic Synthesis and Catalysis Lab

Usual semester

Spring

Published semester

2025/26/2

ECTS

8

Language

Learning outcomes

a) Knowledge - Application of the knowledge learned during the Homogeneous Catalysis, Organic chemistry, and Organometallic theoretical courses in solving practical problems. - Basics in NMR and GC-MS - Standard purification techniques. - Basic synthetic and catalytic reactions b) Abilities - Implementation of catalytic and synthetic processes, independent literature reading, search and evaluation of the data, independent reproduction of literary processes. - Able to assess risk regarding the used chemicals - Able to document his/her work in a reproducible manner. - Able to run chemical reactions with Schlenk, microwave, techniques; able to use electro- and photocatalytic equipment. - Able to prepare GCMS and NMR samples, understand the obtained spectra. - Able to run literature search for a given compound. - Scale-up, from 1mmol to 1 mol - Synthesis in 5 and 20 L reactor, preparing documentation - Thermal risk assessment with reaction calorimetry c) Attitude - Independently develop his organic synthetic practical knowledge on the basis of the acquired knowledge. d) Autonomy and responsibility - During the studies he/she accepts and follows the professional expectations - Highly aware of the risk and obey safety rules.

Course content

laboratory application of the transition metal catalyzed processes presented in current publications and independent processing and evaluation of the theoretical background Gaining experience in the field of advanced preparative and manipulation techniques like semi-micro syntheses in vacuum and inert atmosphere, the Schlenk technique, electro- and photochemical preparations, microwave assisted reactions, chemical vapor deposition, etc. for the preparation of organometallic compounds, among others, transition metal catalysts, clusters, organometallic reagents and precursors. Scale-up of reactions.

Assessment method

Processing the content of scientific publications, literary evaluation in the form of a short presentation at the end of the semester, following by a written exam in theory related to practical work. The tools for assessment will include: home assignment, exam, laboratory report, assessment of labwork. Five-scale assessment.

Bibliography

Piet W. N. M. van Leeuwen: Homogeneous Catalysis, Gary O. Spessard, Gary L. Miessler Organometallic Chemistry, kurrens katalízis témájú tudományos publikációk (minden évben változó) Vogel’s Textbook of Practical Organic Chemistry, 5th Edition (Pearson, 2003.) Csonka István, Kotschy András, Mörtl Mária, Szalay Roland, Szepes László és Vass Gábor: Fémorganikus kémiai és katalízis laboratóriumi gyakorlatok (online jegyzet) Faigl Ferenc, Kollár László, Kotschy András, Szepes László: Szerves fémvegyületek kémiája, (Nemzeti Tankönyvkiadó, Budapest, 2001) Ch. Elschenbroich: Organometallics (Wiley-VCH, 3rd ed., 2006) D.F. Shriver, M.A. Drezdzon: The Manipulation of Air-Sensitive Compounds (Wiley, 2nd ed., 1986) S. Komiya (ed.): Synthesis of Organometallic Compounds - a Practical Guide (Wiley, 1997)

Programmes of the course