Course for international guest/part time students

Faculty

Faculty of Science

Organization

TTK Department of Inorganic Chemistry

Code

theoorgk20em

Title

Theoretical Organic Chemistry

Usual semester

Autumn

Published semester

2026/27/1

ECTS

4

Language

en

Learning outcomes

a) Knowledge - Concepts of mechanistic organic chemistry with the special regards to the electronic- and stereostructure and basic organic reactions.  Chemical bonding and its description by valence bond method and simplified MO theory at qualitative level are of pronounced importance. The basics of stereochemistry. Structure-reactivity relationships that can be interpreted by resonance structures and steric interactions. b) Abilities - The students possess the ability to recognise the mechanisms that can be explained in a unanimous way by the correct use of the general rules mainly of FMO- and HSBA theories discussed in detail in the lectures. Utilization of the acquired knowledge in the prediction of the regioselectivity and stereochemical outcome of certain organic reactions. Ability to find and to explore the information from the literature and the available chemical data bases. c) Attitude - The students are expected to seek to work on their own. They have to be ready to extend their knowledge in the discipline that can be exploited in the realisation of their professional purposes in their carreer. It is also desirable that the students show interest towards organic reaction mechanisms d) Autonomy and responsibility - Hold responsibility for making decisions on his/her study. Make a point of solving separately the study cases assigned by the lecturer to him/her. Responsible application of the knowledge acquired in the course of his/her study.

Course content

Interpretation of the mechanisms of organic transformations, with particular regards to pericyclic reactions, mainly on the basis of Frontier Molecular Orbital (FMO) theory and Hard-Soft Base Acid (HSBA) theory. Theoretical rationalisation of the rate of substituent-dependent regio-and diastereoselectivity of a selection of organic reactions. Chemistry of reactive intermediates (carbenes nitrenes) theoretical interpretation of their generation and transformations.

Assessment method

Written exam at the end of the semester, K(5).

Bibliography

A. Miller, P. H. Solomon, Writing  Reaction Mechanisms in Organic Chemistry  Elsevier Science & Technology Books 1999. F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Kluwer Academic Publishers, New York, Boston, Dordrecht, London, Moscow, 2002 I. Fleming, Pericyclic Reactions, Oxford Chemistry Primers 67, Oxford University Press, 1999. J. Clayden, N. Greeves, S. Warren, Organic Chemistry, 2nd Edition, Oxford University Press, 2012.

Programmes of the course