Course for international guest/part time students

Faculty

Faculty of Science

Organization

TTK Department of Analytical Chemistry

Code

toxick20em

Title

Toxicology

Usual semester

Spring

Published semester

2025/26/2

ECTS

4

Language

hu

Learning outcomes

a) Knowledge:  Knows the basics of toxicology (b) Abilities: Able to use basic tools of toxicology c) Attitude: Strives to develop her/his communication skills independently on the basis of the acquired knowledge (d) Autonomy and responsibility: Adheres to the ethical rules of professional communication.

Course content

Introduction, basic knowledge in toxicology. History of toxicology, technical terms in toxicology. Classification of poisonous substances, description of the poisoning, characteristics of poisons, dose-response relationship. The route of drugs in the human body, toxicokinetics. Absorption, distribution, metabolism and elimination. Toxic effects on the cellular level. Exposure of different organs and the effects of poisons on these. The immune system. Neurotoxicology. Developmental toxicology. Factors and substances damaging the DNA. Mutations. Carcinogenesis. Toxicological aspects of medicine. Main steps of drug development, toxicological aspects of the process, occurrence of adverse effects and drug interactions. Natural toxins – plant- and fungal toxins. Presentation of toxins produced by plants and fungi, poisoning symptoms. Natural toxins – microbial and animal toxins. Presentation of toxins produced by microbes and animals, poisoning symptoms. Xenobiotics, pesticides, other chemicals. Presentation of harmful synthetic substances to which humans may be exposed. Description of plastics, pesticides, food additives and their harmful effects. Metal poisoning. Description of potentially harmful metals. Characterization of heavy metals, presentation of their mechanism of effect and poisoning symptoms. Toxicology of stimulants and drugs of abuse. General and historic description of stimulants and drugs of abuse. Their general effect on the nervous system. Categorization of drugs, specific effects. Categorization and characterization of stimulants. Toxicology of nanomaterials. General description of nanomaterials, presentation of their use. Toxicological risks. Presentation of eventual nervous system effects. Toxicological research methods. Outlook to environmental toxicology, the possibility to use non-mammalian species for toxicological studies. Regulation of the use and production of poisonous substances, risk assessment.

Assessment method

Exam type "A", written exam. Students have the opportunity to give a short presentation, honored with 10% extra points at the exam.

Bibliography

lecture slides

Programmes of the course